CURRICULUM VITAE

        

May 15, 2001

                 

NAME:                                                  ARTHUR BELKNAP STRAUGHN

 

DATE OF BIRTH:                                August 10, 1944

        

PLACE OF BIRTH:                              Durham, North Carolina

        

CITIZENSHIP:                                     U.S.A.

        

MARITAL STATUS:                           Married August 31, 1968 in Knoxville, Tennessee

                                                             Spouse - Maiden Name:      Carol Jean Guthe

                                                             Date of Birth:                        June 13, 1946

                                                             Place of Birth:                       Chicago, Illinois

                                                             Education:                             B.S., Human Ecology

                                                                                                          University of Tennessee

                                                                                                          M.S., Education

                                                                                                          Memphis State University

        

CHILDREN:                                         Tate Lancelot, born February 18, 1977

                                                             Christopher Grant, born November 10, 1981

                     

MILITARY SERVICE:                         U.S. Army  1966-1968 

                                                              Inactive Reserve 1968-1972

        

EDUCATIONAL BACKGROUND:

        

Preparatory :                                         Chapel Hill High School

                                                             Chapel Hill, North Carolina

                                                             Graduated 1962

      

Undergraduate :                                    North Carolina State University

                                                            Raleigh, North Carolina

        

                                                            University of North Carolina

                                                            Chapel Hill, North Carolina

                                                            B.S. in Pharmacy, 1972

        

Post-Graduate :                                    University of Tennessee

                                                            Center for the Health Sciences

                                                            Memphis, Tennessee

                                                            Pharm.D., 1974

 

 Professional Experience:

        

                United States Army                                                          Surgery Assistant

                                                                                                        September 1966 - July 1968

                                              

                North Carolina Memorial Hospital                                    Medication Assistant

                Department of Nursing                                                      June 1971 - May 1972

                Chapel Hill, North Carolina

        

                Division of Pharmacy Practice                                           Instructor

                School of Pharmacy                                                          July 1972 - June 1973

                University of North Carolina

                Chapel Hill, North Carolina

        

                Department of Medicinal Chemistry                                 Assistant Professor

                College of Pharmacy                                                        July 1974 - June 1978

                University of Tennessee

                Center for the Health Sciences

                Memphis, Tennessee

        

                Department of Pharmaceutics                                          Assistant Professor

                College of Pharmacy                                                       July 1978 - June 1979

                University of Tennessee

                Center for the Health Sciences

                Memphis, Tennessee

   

                Department of Pharmaceutics                                           Associate Professor

                College of Pharmacy                                                        July 1979 - June  1985

 

                University of Tennessee

                Center for the Health Sciences

                Memphis, Tennessee                                                       With Tenure, July 1980

        

                Depart. of Pharmaceutical Sciences                                 Professor and Clinical

                College of Pharmacy                                                       Director of the Drug

                University of Tennessee,                                                  Research Laboratory

                Memphis                                                                         July 1985 - present

                Memphis, Tennessee                                                       Post Tenure Review May 2000

                                                                                                       Approved to Direct

                                                                                                       Ph.D. September, l990

 

Course Currently Teaching at UT:

        

                Pharmacokinetics (PHSC 211)

                Pharmacokinetic Research Clerkship (PHSC 411) 

 

Memberships in Societies and Associations

 

                (1972-1979)                            North Carolina Society of Hospital Pharmacists

                (1973-1982)                            American Society of Hospital Pharmacists

                (1974-    )                                American Pharmaceutical Association

                (1974-    )                                Rho Chi, National Pharmacy Honor Society

                (1974-1979)                            Associate Fellow - American College of Apothecaries

                (1975-    )                                Memphis Area Society of Hospital Pharmacists

                (1975-    )                                American Association of Colleges of Pharmacy

                (1975-    )                                American Association for the Advancement of Science

                (1981- 1987)                           Academy of Pharmaceutical Sciences

                (1982-    )                                American College of Clinical Pharmacy

                (1984-    )                                Memphis-Shelby County Pharmaceutical Society   

                (l985-    )                                 Sigma Xi

                (l986-    )                                 Drug Information Association

                (1987-    )                                American Association of Pharmaceutical Scientists

                (1989-    )                                Tennessee Pharmaceutical Association

                (1992-    )                                Phi Lamda Sigma, National Pharmacy Leadership Society

 

Referee for:

 

                Drug Intelligence and Clinical Pharmacy

                American Journal of Hospital Pharmacy

                Journal of Pharmaceutical Sciences

                Journal of Pharmacokinetics and Biopharmaceutics

                Clinical Pharmacy

                Pharmaceutical Research

                Pharmacotherapy

 

Reviewer for:

       

                AMA Drug Evaluations

        

Student Extracurricular Activities:

 

                Student APhA                                                                      1970-1972

                Drug Abuse Education Committee                                        1970-1972

 

Consultantships:

                Schering/Key Pharmaceuticals, Inc., Miami, FL

                Cord Laboratories, Broomfield, CO

                Glaxo Laboratories, Research Triangle Park, NC

                Purdue Frederick Company, Norwalk, CT

                DuPont Pharmaceuticals, Wilmington, DE

                IDR, Inc., Gaithersbug, MD

                ClinDAR, Inc., Durham, NC

                Martec Pharmaceutical, Inc., Kansas City, MO

                Kos Pharmaceuticals, Inc., Miami, FL

                The Upjohn Co., Kalamazoo, MI

                Pracon, Inc., Reston, VA

                Harris Laboratories, Lincoln, NE

                Seigfried Pharmaceuticas, Basel, Switzerland

                Med. Ed., Inc., Hardford, CN

                Carnrick Pharmaceuticals, NJ

                Sano/Elan Corporation, Miami, FL

                Timerx Technologies, Patterson, NY

                Daniels Pharmaceuticals, St. Petersberg, FL

                Kemic Research, Canada

                Faulding Pharmaceuticals, Adalade, Australia

                Anapharma, Canada

 

Honors and Awards:   Teacher of the Year 1991 (Class of 1993)

                                                Elected to Phi Lamda Sigma Pharmacy

                                                                                Leadership Society 1992

                                                Student Goverment Association Excellence in                          

                                                                                Teaching Award 1993        

                                                Teacher of the Year 1993 (Class of 1995)

                                                Teacher of the Year 1995 (Class of 1997)

 

 Ancillary Appointments:

        

                College of Pharmacy

        

                Member, Task Force on Professional Practice (1976)

                Member, U.T. Statewide Pharmacy Education Program Advisory Committee (1975-1977)

                Member, Task Force on Student Cheating (1976)

                Academic Student Advisor (1975-      )

                Member, Task Force on Student Clerkships (1976)

                Member, Academic Standing and Promotion Review Committee (1976-1977)

                Member, Faculty Advisory Council (1977-1983)

                Member, Admissions Committee (1978-1980, 1988-1990)

                Member, Curriculum Committee (1980-1985, 1990-1992, 1999-  )

                Member, Search Committee for Pharmaceutics Chairman (l988-89)

                Member, Search Committee for Clinical Pharmacy Chair (l990)

                Director, Graduate Admissions in Pharmaceutics (l989-1993)

                Member, Promotion and Tenure (l990-1994)

                Member, Planning and Assessment (l993-1994)

                Member, Technology Assessment (1993-1998)                

                               

               UT, Memphis

 

                                Member, Faculty Senate (1977-1983, 1988-    )

                                Chairman Budget and Benefits (1994-      )

                                 Faculty Senate Executive Council (1980-1982)

                                Graduate Faculty Level to Direct Students (1979-    )

                                Member, Computer Committee (1981-1983)

                                Chairman, Governance & Credentials Committee (1981-1983)

                                Board of Directors, UTCHS Faculty Club (1981-1986)

                                Faculty Senate, Parliamentarian (1982-1983)

                                Member, Ad Hoc Committee on Faculty Evaluation (1983-1984)

                                Chairman, Membership Committee, UTCHS Faculty Club(1985-86)

                                Faculty Counselor to President Boling (1985-1987)

                                Member, Academic Information Advisory Committee (l988-92)

                                                Chairman (l989-92)

                                Member, Institutial Review Board (l990-    )

                                Member, UT Parking Authority (l991-     )

                                Member, Ad Hoc Committee Graduate Reserach Council (1992-1993)

                                Member, UT Student Advisory Council (l993-1995)

                                Member, UT Campus Support Services (1996 -       )

 

                Research Project Director for the following Doctor of Pharmacy

                Candidates:

        

                1.             Steve K. Huffines                   2.             Charles D. Rutledge

                3.             David E. Stewart                    4.             John Fisher

                5.             James Eldridge                       6.             Leslie J. North

                7.             James F. Koren                      8.             Sharon Ternullo

                9.             E. Richard Kessler                 10.           Trevia Walton

                11.           Jane Miller                             12.           Greg Drexler

                13.           Mike Hayes                           14.           Dave DiPersio

                15.           Robert Henderson                  16.           David Butler

                17.           Diane Drain                            18.           Desouky F. Fayed

                19.           Timothy Mickle

      

 Graduate Student Committees

        

                1.             Martin K.T. Yau, Pharmaceutics

                2.             E. Armstrong, Pharmacy Administration

                3.             R. Rackley, Pharmaceutics

                4.             V. Vashi, Pharmaceutics        

                5.             Tina Ursic, Pharmacy Administration

                6.             Denise Ladd, Nursing

                7.             Reba Roberts, Pharmaceutics

 

Graduate Students Directed

 

                1. Robbie Kidd

 

Publications:

       

 

            1.             "A Novel Pharmacokinetic Slide Rule for Dosage Computations",  A. B. Straughn,  Copyright 1974.

        

2.             "Assurance of Drug Quality (Bioavailability)", J. H. Coleman and A. B. Straughn, Diseases of the Nervous System, 36:63 (1975).

        

3.             "Warfarin Induced Hypoprothrombiremia:  Potentiation of Hyperthyroidism",  T. Self, M. Weisburst, E. Wooten, A. B. Straughn, and J. Oliver, J.A.M.A., 231:1165 (1975).

        

4.             "Effect of Hyperthyroidism on the Hypoprothrombinemic Response to Warfarin",  T. H. Self, A. B. Straughn and M. R. Weisburst, Am. J. Hosp. Pharm., 33:387 (1976).

        

5.             "Bioavailability of Eleven Sulfisoxazole Tablets", G. Slywka, A. P. Melikian, A. B. Straughn and M. C. Meyer, J. Pharm. Sci., 33:387 (1976).

        

6.             "Bioavailability of Eleven Phenytoin Products", A. P. Melikian, A. B. Straughn,  G. W.A. Slywka, P. L. Whyatt and M. C. Meyer, J. Pharmacokin. Biopharm., 5:133         (1977).

        

7.             "Drug Interactions Involving Aminosalicylic Acid", M. C. Meyer, T. H. Self and A. B. Straughn, Rev. Drug Interactions, 2:107 (1977).

        

8.             "Estimations of Drug Dosing Regimens with a Pharmacokinetics Slide Rule",  A. B. Straughn, C. A. Cruze and M. C. Meyer, Am. J. Hosp. Pharm., 34:197 (1977).

        

            9.             "Meprobamate Bioavailability Monograph", M. C. Meyer and A. B. Straughn, J.A.Ph.A.,  NS17:173 (1977).

        

10.           "Digitalis Intoxication", C. E. Kossman, A. B. Straughn and B. O. McGraw,  Tenn. Med. Assoc. J., September 1977, P. 644.

       

11.           "Factors Affecting the Bioavailability of Chlorothiazide in Man", M. C. Meyer and A. B. Straughn, Curr. Ther.  Res., 22:573 (1977).

        

12.           "The Relative Bioavailability of Meprobamate Tablets in Man", M. C. Meyer, A. P. Melikian and A. B. Straughn, J. Pharm. Sci., 67:129 (1978).

        

13.           "The Bioavailability of Sulfadiazine Solutions, Suspensions and Tablets in Man",  M. C. Meyer, A. B. Straughn, G. Ramchander, J. C. Cavagnol and A. F. B. Mabadeje,  J. Pharm. Sci., 67:1659 (1978).

 

14.           "The Influence of Dosage Form on Papaverine Bioavailability", M. C Meyer,  R.  Gollamudi and A. B.  Straughn, J. Clin. Pharmacol., 19:435 (1979).

 

15.           "Simultaneous Determination of Methenamine and Formaldehyde in the Urine of Humans after Methenamine Administration", R. Gollamudi, M. C. Meyer and A. B. Straughn, Biopharm. Drug Dispos., 1:27 (1979).

 

16.           "The Bioavailability of Chlorothiazide Tablets in Man", A. B. Straughn, A.P. Melikian and M. C. Meyer, J. Pharm. Sci., 68:1099 (1979).

 

17.           "A Multiple-Dose Study of Sustained-Release Theophylline and Aminophylline", M. C. Meyer, A. B. Straughn and P. Lieberman, Chest, 78:300 (1980).

        

18.           "Bioavailability of Microsize and Ultramicrosize Griseofulvin Products in  Humans", A. B. Straughn, M. C. Meyer, G. Raghow and K. Rotenberg, J. Pharmacokin.Biopharm., 8:34 (1980).

        

19.           "Evaluation of Enzyme Immunoassay, Radioassay, and Radio-immunoassay of     Serum Methotrexate, with Liquid Chromatography as a Standard", R. G. Buice, W. E. Evans, J. Karas, C. A. Nicholas III, P. Sidhu, A. B. Straughn, M. C. Meyer and W. R. Crom, Clin. Chem., 26:1902 (1980).

       

20.           "Pharmacokinetics of Propylthiouracil Upon P. O. Administration in Man", H. P. Ringhand, W. A. Ritschel, M. C. Meyer, A.B. Straughn and T. Hardt, Intl. J. Clin. Pharmacol. Ther. Toxicol., 18:3011 (1980).

               

21.           "Urinary Excretion of Methenamine and Formaldehyde: Evaluation of 10 Methenamine Products in Humans", R. Gollamudi, A. B. Straughn and M. C. Meyer, J. Pharm. Sci., 70:596 (1981).

 

22.           "Chloramphenicol Clearance in Infants", G. J. Burckart, F. Barrett, A. B. Straughn, S. R. Ternallo, J. Clin. Pharm., 22:49 (1982).

        

23.           "HPLC Determination of Benzthiazide in Biological Fluids", M. C. Meyer, P. Hwang, A. B. Straughn, K. Rotenberg, Biopharm. Drug Disposition, 3:1 (1982).

        

24.           "Serious Bioavailability Problems With a Generic Prolonged Release Quinidine Gluconate Product", M. C. Meyer, A. B. Straughn, P. Lieberman, J. Jacob, J. Clin.Pharmacol., 22:131 (1982).

        

            25.           "Model-Independent Steady-State Volume of Distribution", A. B. Straughn, J. Pharm. Sci., 71:597 (1982).

 

26.           "Serum Salicylate Concentrations Achieved by AspirinAdministered at Six and Twelve Hour Dosing Intervals", C. D. Butler and A. B. Straughn, Clinical Pharmacy, 1:458 (1982).

        

27.           "Relative Bioavailability of Acetazolamide Tablets", A. B. Straughn, R. Gollamudi and M. C. Meyer, Biopharm. Drug Disposition, 3:75 (1982).

        

28.           "Noneffect of Rifampin on Theophylline Disposition in Rabbits", T. H. Self, M. M. Self, J. P. Worden, W. S. Taylor and A. B. Straughn, Res. Comm. Chem.Path. Pharm., 32:921 (1982).

      

29.           "Isoniazid-Induced Alterations in Theophylline Pharmacokintics", J. R. Thompson, G. J. Burckart, T. H. Self, R. E. Brown and A. B. Straughn, Curr. Ther. Res., 32:921(1982).

        

30.           "Bioavailability of Propylthiouracil in Humans", H. P. Ringhand, W. A. Ritschel, M. C. Meyer, A. B. Straughn and B. E. Cabana, J. Pharm. Sci., 72:1409 (1983).

        

31.           "Absorption of Phenobarbital from Tablets and Elixir", M. C. Meyer, A. B. Straughn, G. Raghow, W. L. Schary and K. S. Rotenberg, J. Pharm. Sci., 73:485       (1984).

        

32.           "Plasma Levels of Ethaverine After Oral Administration to Humans", M. C. Meyer, G. Raghow and A. B. Straughn, Biopharm. Drug Dispos., 4:401 (1983).

        

33.           "Bioequivalence, Dose Proportionality and Pharmacokinetics of Naltrexone After Oral Administration", M. C. Meyer, A. B. Straughn, M. Lo, W. L. Schary, C. C. Whitney, J. Clin. Psychiatry, 45:15 (1984).

        

34.           "Effect of Rifampin on Theophylline Disposition", A. B. Straughn, R. Henderson, P. Lieberman, T. H. Self, Ther. Drug Monitoring, 6:153 (1984).

        

            35.           "Administration of Theo-Dur Once-A-Day vs. Twice-A-Day," A. B. Straughn, M. C.

Meyer, A. L. Golub, M. A. Gonzalez, In: Sustained Release Theophylline and Nocturnal Asthma,p. 116: Eds. A.F. Isls and P. von Wichert. Excerpta Medica, Amsterdam.

        

36.           "A Chronopharmacokinetic Model for Sustained Release Formulation," A. B. Straughn, M. C. Meyer, A. L. Golub and M. A. Gonzalez, Annual Reviews of Chronopharmacology 1:92 (1985).

        

 

37.           "Bioavailability of Dyphylline and Dyphylline-Guiafenesin Tablets in Humans," A.              B. Straughn, G. C. Wood, G. Raghow and M.C. Meyer, J. Pharm. Sci. 74:335 (1985).

 

38.           "Comparison of High Pressure Liquid Chromatography and Fluorescence Polarization Immunoassay Methods in a Theophylline Pharmacokinetic Study," R. L. Lalonde, M. B. Bottorff and A. B. Straughn, Ther. Drug Monitoring, 7:442 (l985).

       

39.           "Determination of Free Disopyramide Plasma Concentrations Using Ultrafiltration  and EMIT," G. Raghow, M.C. Meyer and A.B. Straughn. Ther. Drug Monitoring, 7:467 (l985).

        

40.           "Bioavailability of Seven Furosemide Tablets in Man," A. B. Straughn, G. C. Wood, G. Raghow, and M. C. Meyer, Biopharm. Drug Dispos. 7:113 (l986).

        

41.           "Dialzability and Pharmacokinetics of Indomethacin in Adult Patients with End-    Stage Renal Disease," V.A. Skoutakis, C. Carter, N.J. Wojciechowski, A.B. Straughn, and M.C. Meyer. Drug Intelligence and Clin. Pharm., 12:956 (l986)

        

42.           "Comparison of High Pressure Liquid Chromatography and Fluorescence Polarization Immunoassay to Assess Quinidine Pharmacokinetics," M.B. Bottorff, R.L. LaLonde, and A.B. Straughn. Biopharm. Drug Dispos., 8:213 (1987).

        

43.           "Effect of Food on Absorption of Cefuroxime Axetil," A.B. Straughn, D.A. Finn, and M.C. Meyer. Biopharm. Drug Dispos., 8:519 (l987).

               

44.           "Influence of a Standard Meal on the Absorption of a Controlled-Release Pseudoephedrine Suspension," D.A. Graves, M.T. Wecker, M.C. Meyer, A.B.Straughn, L.P. Amsel, O.N. Hinsvark, A.E. Bhargava and K.S. Rotenberg. Biopharm.and Drug Dispos., 9:267 (l988).

 

45.           "The Absorption of Sustained-Release Methylphenidate Formulations Compared to an  Immediate-Release Formulation," K.S. Partick, A.B. Straughn, E.J. Jarvi, G.R. Breese and M.C. Meyer. Biopharm. and Drug Dispos. 10:165 (1989).

      

46.           "A Circadian Rhythm in Theophylline Disposition During a Constant-RateIntravenous Infusion of Aminophylline in the Dog," R.J. Rackley, M.C. Meyer and A.B. Straughn. J. Pharm. Sci. 77:658 (l988).

        

47.           "Chronopharmacokinetic Simulation of a Circadian Rhythm in Theophylline Disposition During a Constant-Rate Intravenous Infusion of Aminophylline in theDog," R.J. Rackley, A.B. Straughn and M.C. Meyer, Ann. Review of Chronopharmacology (1988).

 

48.           "Gas Chromatographic-Mass Spectrometric Analysis of Plasma Oxybutynin Using aDeuterated Internal Standard," K.S. Partick, J.S. Markowitz, E.J. Jarvi and A.B.Straughn, M.C. Meyer, J. of Chromatogrtaphy 487:91 (l989).

        

49.           "In Vitro and In Vivo Evaluation of Seven 50mg and 100mg Nitrofurantoin Tablets,"  M.C. Meyer, G.C. Wood and A.B. Straughn, Biopharm. and Drug Dispos. 10:321(l989).

        

50.          "Gas Chromatographic-Mass Spectrometric Analysis of Plasma Nifedipine" K.S.Patrick, E.J. Jarvi, A.B. Straughn and M.C.Meyer, J. Chrom. (Biomed. App.) 495:123(l989)

        

51.           "The Effect of Raising Gastric pH with Ranitidine on the Absorption and Elimination of Theophylline from a Sustained-Release Theophylline Tablet," C.J. Betlach, A.B. Straughn, M.C. Meyer, M. Bailer, V.I. Vashi, P. Lieberman and M.A.Gonzalez, Pharm. Res. 8:1512 (1991).

 

52.           "Circadian Rhythms in Theophylline Disposition: Simulations and Observations in the Dog," R.J. Rackley, M.C. Meyer and A.B. Straughn, J. Pharm. Sci. 50:835 (l991).

        

53.           "Postmenopausal Steroid Replacement with Micronized Dehydroepiandrosterone (DHEA): Preliminary Oral Bioavailability and Dose Proportionality Studies," J.E. Buster, P.R. Casson, A.B. Straughn, et al,  Am. J. Obstet. Gynecol. (in Press).

        

54.           "The Bioinequivalence of Carbamazepine Tablets with a Historyof Clinical Failures," M.C. Meyer, A.B. Straughn, et al, Pharm. Res. 9:1612 (l992).

        

55.           "Quantitative Detrmination of Cyclobenzaprine in Human Plasma by High Pressure Liquid Chromatography," P.T.R. Hwang, D.A.Young, A.B. Straughn, M.C. Meyer, J. Liquid Chrom. 16:1163(1993).

 

56.           "The Effect of Gastric pH on the Absorption of Controlled-Release Theophylline forms in Humans,” M.C. Meyer, A.B. Straughn, E.J. Jarvi, G.C. Wood, V.I. Vashi, P. Hepp, and J. Hunt, Pharm. Res. 10:1037(1993).

 

57.           "Biopharmaceutical Factors in Seizure Control and Drug Toxicity,” M.C. Meyer and A.B. Straughn, Am J. Hosp. Pharm. 50:S17 (1993).

 

58.           "Comparative Steady-State Bioavailability of Theo-24 and Theo-Dur in Healthy    Men,”  G. Cefali and A.B. Straughn, Ann. Allergy, 72:218 (1994).

 

59.           "Oral Dehydroepiandrosterone in Physiologic Doses Modulates Immune Function in Postmenopausal Women,”  P.R. Casson, R.N. Andersen, H.G. Herrod, F.B. Stentz, A.B. Straughn, G.E. Abraham, and J.E. Buster, Am. J. Obstet. Gynecol., 169:1536 (1993).

 

60.           "Effect of Meals and Dosage-Form Modification on Theophylline Bioavailability from a 24-Hour Sustained-Release Delivery System,” M.A. Gonzalez and A.B. Straughn, Clinical Therapeutics, 16:804 (1994).

 

61.           "Pharmacokinetic Comparison of a Once-Daily and Twice-Daily Theophylline Delivery System,” M.A  and A.B. Struaghn, Clinical Therapeutics, 16:686 (1994).

 

62.           "Replacement of Dehyroepiandrosterone Enhances T-Lymphocyte Insulin Binding in Postmenopausal Women,” P.R. Casson, L.C. Faquin, F.B. Stentz, A.B. Straughn, R.N. Andersen, G.E. Abraham, and J.E. Buster, Fertility and Sterility                 63:1027 (1995)

               

            63.           "'Pavlovian’ Food Effect on the Enterohepatic Recirculation of Piroxicam,” J.E. Polli, S. Bigora, D. A. Piscitelli, A.B. Straughn, and D. Young, Biopharm. Drug Disp. 17:635 (1996).

 

            64.           "Lack of In Vivo/In Vitro Correlations for 50 mg and 250 mg Primidone Tablets,” M.C. Meyer, A. B. Straughn, R.M. Mhatre, V. Shah, R.L. Williams and L. Lesko, Pharm. Res. (1998).

 

65.     "The Relative Bioavailability and In Vivo-In Vitro Correlations for Four Marketed Carbamazepine Tablets,” Meyer, MC, Straughn, AB, Mhatre, R, Shah, V, Williams, RL and Lesko, L., Pharm. Res.  15:1787-1791(1998)

 

66.      “The Relative Bioavailability and In Vivo-In Vitro Correlations for Four Marketed Carbamazepine Tablets”. Meyer, MC, Straughn, AB, Mhatre, R, Shah, V, Williams, RL and Lesko, L., Pharm. Res.  15:1787-1791 (1998).

 

67.           "Pharmacokinetics of Chlorpheniramine, Phenytoin, Glipizide and Nifedipine in an Individual Homozygous for the CYP2C9*3 Allele,” Kidd, RS, Straughn, AB, Meyer, MC, Blaisdell, J, Goldstein JA, Dalton JT.  Pharmacogenetics 9:71-80 (1999).

 

            68.           "Bioequivalence of Methylphenidate Immediate-Release Tablest Using a Replicate Study Dosing to Characterize Intrasubject Variability,” Meyer, MC, Straughn, AB, Jarvi, EJ, Partick, KS, Pelsor, FR, Williams, RL, Patnaik, R, Chen, M, Shah, VP. Pharm. Res. 17:381-384 (2000).

 

             69.           "The Effect of Gelatin Cross-Linking on the Bioequivalence of Hard and Soft Gelatin Acetaminophen Capsules,” Meyer, MC, Straughn, AB, Mhatre, R, Hussain, A, Sha, VP, Bottom, C, Cole, E, Lesko, L, Malinoski, H, Williams, RL.  Pharm. Res. 17:962-6 (2000)

 

 

69.     "Bioequivalence of Immediate-Release Theophylline Capsules,” Meyer, MC, Jarvi, EJ, Straughn, AB, Pelsor, RP, Williams, RL, Shah, VP. Biopharm. Drug Disp. 20:417-19 (2000).

 

 

 70.     “Carbamazepine level-A in vivo-in vitro correlation (IVIVC): a scaled convolution based predictive.” Veng-Pedersen P, Gobburu JV, Meyer MC, Straughn AB.  Biopharm Drug Dispos. 2000 Jan;21(1):1-6.

 

 

71.      “Variability in the Bioavailability of Phenytoin Capsules in Males and Females. Meyer, MC, Straughn, AB, Mhatre, RM, Shah, VP, Chen, ML, Williams, RL and Lesko, LJ. Pharm. Res. 18:394-397 (2001).

 

 Abstracts:

        

1.             "Use of a Pharmacokinetic Slide Rule in Teaching Pharmacokinetics”, AACP Annual Meeting, Minneapolis, MN, July, 1976.

        

2.             "Effect of Hyperthyroidism on the Hypoprothrombinemic Response to Warfarin", American Pharmaceutical Association Annual Meeting, San Francisco, CA, October, 1975.

        

3.             "Bioavailability of Eleven Sulfisoxazole Tablets", Academy of Pharmaceutical Sciences Annual Meeting, Atlanta, GA, November, 1975.

        

4.             "Bioavailability of Eleven Diphenylhydantoin Capsules", Academy of    Pharmaceutical Sciences Annual Meeting, Atlanta, GA, December, 1975.

 

            5.             "Bioavailability of Papaverine Dosage Forms", ASHP Mid-Year Meeting, Atlanta, GA, December, 1977.

       

6.             "Bioavailability of Five Warfarin Products in Humans, ASHP Mid-Year Meeting, Las Vegas, NV, December, 1979.

               

7.             "Steady-State Bioavailability of Two Sustained-Release Theophylline Preparations", ASHP Mid-Year Meeting, Las Vegas, NV, December, 1979.

        

8.             "Effect of DOSS on the Absorption of Orally Administered Digoxin", ASHP Mid-Year Meeting, San Francisco, CA, December, 1980.

        

9.             "Pharmacokinetic Analysis with Statistical Moments", ASHP Mid-Year Meeting, San Francisco, CA, December, 1980.

 

            10.           "Comparison of Six and Twelve Hour Dosing of Aspirin", ASHP Mid-Year Meeting,

                                San Francisco, CA, December, 1980.

        

11.           "In Vitro Predictors of Theophylline Bioavailability I: Correlations Between Fraction Dissolved and Fraction Absorbed", Academy of Pharmaceutical Sciences, Orlando, FL November, 1981.

        

12.           "In Vitro Predictors of Theophylline Bioavailability II: Correlations with  Statistical Moments", Academy of Pharmaceutical Sciences, Orlando, FL November, 1981.

        

            13.           "Hemoperfusion in Theophylline Toxicity", ASHP Mid-Year Meeting, New Orleans, LA, December, 1981.

        

14.           "Pharmacokinetics of Ceftazidime in Normal Subjects and EndStage Renal Disease", Interscience Conference on Antimicrobial Agents and Chemotherapy", Miami        Beach, FL October, 1982.

               

15.           "Ceftazidime Pharmacokinetics During Continuous Ambulatory Peritoneal Dialysis (CAPD) and Intermittent Peritoneal Dialysis (IPD)", American College of Clinical Pharmacy, Washington, D.C., July, 1983.

 

16.           "In Vitro Prediction of Steady-State Fluctuations in Theophylline Concentrations", American College of Clinical Pharmacy, Washington, D.C., July, 1983.

             

17.           "A Chronopharmacokinetic Model for Sustained-Release Formulations", First International Montreaux Conference: Biological Rhythms and Medications, Montreaux, Switzerland, March, 1984.

        

18.           "Disposition Kinetics of Controlled-Release Theophylline Dosed at 12 and 24 h    Dosing Intervals", Academy of Pharmaceutical Sciences, Montreal, Canada, May, 1984.

        

19.           "Bioavailability of Cefuroxime Axetil Administered After Food," Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, D.C., October, 1984.

        

20.           "Steady-State Aspirin and Metabolite Pharmacokinetics After Administration of Immediate and Controlled-Release Dosage Forms," American College of Clinical Pharmacy, Orlando, FL, July, 1985.

        

21.           "Effect of Gastric pH on the Absorption of Theophylline from Sustained-Release                                                 Formulations," American Association of Pharmaceutical Scientists, Boston, MA,  June, l987.

 

22.           "Chronopharmacokinetic Simulation of a Circadian Rhythm inTheophylline Disposition During a Constant    -Rate Intravenous Infusion of Aminophylline in the Dog," Third International Conference of Chronopharmacology, Niece, France, March, 1988.

 

23.           "Chronopharmacokinetics with Sustained-Release Theophylline,"Third International Conference on Chronopharmacology, Niece, France, March, l988.

       

24.           "Evidence for Circadian Change in Volume of Distribution of Theophylline in the Dog. American Association of Pharmaceutical Scientists, Orlando, FL  Nov. l989.

        

25.           "High Fat Meal Effects on the Single Dose Pharmacokinetics of a new Once-a-Day Theophylline Tablet, 45th Annual Congress of the American College of Allergy                and Immunology, Los Angeles,CA, Nobember 1988.

 

26.           "Multiple-Dose Pharmacokinetic Evaluation of a Once-Daily Theophylline Tablet Doses to Pediatric Asthmatics", Third Eastern Allergy Conference, Bal Harbour, FL Apr 1990.

        

27.           "Effect of Tablet Halving on the Pharmacokinetics of Theophylline from Uni-Dur", ACCP Annual Meeting, Kansas City, MO, Aug 1990.

        

28.           "Bioavailability of Eight Trichlormethiazide Tablet Formulations,"  AAPS Annual Meeting, Atlanta, GA, Nov 1989.

       

29.           "Gastric pH and Absorption of Cr-Theophylline Products in Man", AAPS Annual Meeting, Atlanta, GA, Nov 1989.

 

            30.           "Bioequivalence of Methylphenidate Tablets", AAPS Annual Meeting, Las Vegas, NV, Nov 1990       

 

            31.           "Influence of Gastric pH on the Absorption of Diazepam", AAPS Annual Meeting, Las Vegas, NV, Nov 1990.

        

32.           "Bioequivalence of Theophylline Immediate Release Tablets" AAPS Annual Meeting, Las Vegas, NV, Nov 1990.

        

33.           "Multiple Dose Pharmacokinetic Evaluation of a Once Daily Theophylline Tablet Dosed     to Pediatric Asthmatics", 3rdEastern Allergy Conference, Bal Harbour, FL  1990.

       

34.           "Pharmacokinetics of Uni-Dur, a Once Daily Theophylline" Annual Conference of the European Respiratory Society, Brussels, Belgium Sept 1991.

        

35.           "Formulation Dependent Steady State Chronopharmacokinetics of Theophylline", AAPS Annual Meeting, Washington, DC, Nov 1991.

        

36.           "The Bioavailability of Multi-Source Amitriptyline Formulations", AAPS Annual Meeting, Washington, DC, Nov 1991.

        

37.           "Effect of Reformulation on the Bioavailability of 50 mg Primidone Tablets", AAPS Annual Meeting, SanAntoino, TX Nov 1992.

 

38.           "The effect of Food on the Bioavailability of Doxycycline Hyclate Capsules and Tablets," Annual Meeting, Orlando, FL Nov 1993.

 

39.           "The Effect of Reformulation on the bioequivalence of 250 mg Primidone Tablets,”AAPS Annual Meeting, Orlando, FL Nov 1993.

 

40.           "Bioequivalence (BE) of Multi_source Carbamazepine (CBZ) Tablets,” AAPS Annual Meeting, San Diego, CA Nov 1994.

               

41.           "Correlation Between In Vitro Dissolution and In Vivo Oral Bioavailability of Piroxicam (PR) Capsules,” AAPS Annual Meeting, San Diego, CA Nov 1994.

 

42.           "Pavlovian Food Effect on Enterohepatic Recirculation Monitored by Drug Plasma Concentration: Piroxicam Example,” AAPS Annual Meeting, San Diego, CA Nov 1994.

 

43.           "Use of the Heidelberg Capsule to Evaluate the Effects of Food on the    Bioavailability of an Enteric-Coated Tablet with Rapid Abosrption and        Elimination,” AAPS Annual Meeting, San Diego, CA Nov 1994.

 

            44.           "Bioequivalence(BE) of Different Lots of Dilantin,” AAPS Annual Meeting, Seattle, WA Oct 1996.

 

            46.           "Bioequivalence(BE) of Marketed Multisource Desipramine (DE) Products and the Effects of Gender Differences,” AAPS Annual Meeting, Seattle, WA Oct 1996.

 

            47.           "Carbamazepine Level-A In Vitro-In Vivo (VV) Correlation: A scaled Convolution Based Predictive Approach,” AAPS Annual Meeting, Seattle, WA Oct 1996.

 

            48.           "The Effects of Cross Linking in Gelatin Capsules on the Bioequivalence of Acetaminophen”, AAPS Annual Meeting, Boston, MA Nov 1997.

 

            49.           " The Effect of Hormonal Fluctuation During the Menstrual Cycle on the Pharmacokinetics of Tobramycin”, AAPS Southern Regional Discussion jJGroup, Oxford, MS May 1998.

 

            50.           " The Pharmacokinetics of Chlorpheniramine, Phenytoin, Nifepidine and Glipizide in an Individual Homozygous for the LEU359 Allele of CYP 2C90”, AAPS Southern Regional Discussion Group, Oxford, MS May 1998.

 

            51.           "Pharmacokinetics of Chlorpheniramine, Phenytoin, Glipizide and Nifedipine in an Individual Homozygous for the CYP2C9*3 Allele”, American Association of Pharmaceutical Scientists Annual Meeting November 1998.

 

            52.           "Determination of 5-Aminolevulinic Acid (ALA) in Human Plasma Samples by HPLC”, American Association of Pharmaceutical Scientists Annual Meeting November 1998.

 

            53.           "Pharmacokinetics Study Comparing RingCapTM Tablets and Matrix Tablets”, Controlled Release Society Annual Meeting May 2000.

 

Invited Presentations:

        

            1."Digoxin Intoxication: Case Study", Grand Rounds UTCHS,  Memphis, Tennessee, Aug, 1976.

        

2."Pharmacokinetic Considerations in Aminoglycoside Therapy", Arkansas Society of Hospital Pharmacists Fall Seminar, Little Rock, Arkansas, Sept, 1976.

        

3. "Basic Concepts in Clinical Pharmacokinetics", Seattle Area Society of Hospital Pharmacists Annual Seminar, Seattle, Washington, March, 1977.

 

4."Bioavailability Aspects of Drug Therapy", Annual St. Thomas Moore-Roche Therapeutic Symposium, Nashville, Tennessee, Aug, 1977.

        

5."Basic Pharmacokinetics", UTCHS College of Medicine Continuing Education Program, Memphis, Tennessee, March, 1978.

       

6."The Digitalis Glycosides" and "The Aminoglycosides Antibiotics", Radioassay  Applications in Pharmacology and Hematology, Veterans Administration Hospital, St. Louis, Missouri, Apr, 1978.

               

7."Pharmacokinetic Aspects of Toxicology", Clinical Toxicology and Pharmacology, VA Hospital, Memphis, Tennessee, June, 1979.

         

8."Drug Dosing Concepts", Clinical Toxicology and Pharmacology, VA Hospital, Memphis, Tennessee, August 27, 1980.

        

9."A Diurnal Pharmacokinetic Model for Multiple Dose Theophylline", College of Pharmacy, University of Utah, Salt Lake City, Utah, Apr, 1983.

        

         10.  "Chronopharmacokinetics", College of Pharmacy, Medica College of Virginia, Richmond, Virginia, May, 1983.

        

         11.  "Power Analysis in Bioavailability Studies", Glaxo Laboratories, Research Triangle Park, N.C., Dec, 1983.

        

         12.  "Practical Aspects of Therapeutic Drug Monitoring", Winchester County Society of Hospital Pharmacists, Valhalla, N.Y., May, 1984.

        

         13.  "Administration of Theo-Dur Once-A-Day vs. Twice-A-Day" Sustained Release Theophylline and Nocturnal Asthma Workshop, Burgenstock, Switzerland, July,         1984.

        

         14.  "Interpretation of Bioavailability Data for the Practitioner", ASHP Mid-Year Clinical, New Orleans, LA, Dec, l985.

               

15. "Controversies in Sustained-Release Theophylline", HamiltonCo. Pharmaceutical Society, Chattanooga, TN, March, l986.

        

         16.  "Absorption of pH Dependent SR Theophylline in Patients with Normal and Decreased Gastric Acid Production," Schering Corporation, Miami, FL, June, 1987.

 

17. "PharMACokinetix: A Pharmacokinetic Simulation Tool, 18thAnnual Meeting of  EDUCOM, Los Angles, CA, November, l987.

            

18. "Bar Code Reading for In-process Quality Control of Clinical Data," 24th Annual  Meeting of the Drug Information Association, Toronto, Canada, July 1988.

        

        19.  "Pharmacokinetics of a New Once-a-Day Theophylline", 45thAnnual Congress of  the  College of Allergy and Immunology. LosAngles CA, Nov, l988.

        

        20."Optical Scanning for Clinical Data Capture and Tracking" DIA Workshop on  Clinical Data Management, Philadelphia, PA, Apr, 1989.

        

         21.  "Pharmacokinetics of 'Once-A-Day' Theophylline, Cancun Conference, Cancun, Mexico, May,  l989.

        

         22.  "Dosage Regimens for SR Theophylline", 2nd International Colloquium on Progress  in Pulmonary Medicine, Deauville,  France, June, l989.

 

         23.  "Pharmacokinetics of a New Onec-a-Day Theophylline, Medical Education Conference, Dallas, Tx, Sept, l989.

        

         24.  "Pharmaceutical Aspects of Theophylline Dosage Forms",  Medical Education  Conference, Houston, TX, Nov, l989.

        

         25.  "Dosing Considerations of Once-a-Day Theophylline, MedicalEducation  Conference, New York, NY,  Dec,  l989.

       

         26.  "Bathrooms and Bioinequivalence:Problems with Carbamazepine, Schering Research, Miami, FL, March,  l989.

         

         27.  "Carbamazepine Bioavailability", Ciba-Giegy, Morristown, NJ,  Oct 1990.

        

         28.  "Sustained-Release Theophylline", Carnrick Pharmaceuticals, Dallas TX, Apr, 1992.

       

         29.  "Ethics and the Industrial/Academic Relationship”, Ethics in Medicine Seminar    Series, Memphis, TN, June, 1993.

        

 30."How We Got the Bucks- Pharmaceutical Studies,”  A UTRC Hertel Event, Memphis, TN, May, 1994 and   April, l995.

 

 31."Pharmacokinetic Workshop Using Stella Simulation Software,”  Faulding  Pharmaceuticals, Adelaide, Australia, December 1994.

 

         32.  "Optomization of Drug Formulations Using In Vitro/In Vivo Modeling with STELLA”, Kemic Course in the Pharmaceutical Scineces Philidelphia PA, May 1997

        

         33.  "IVIVC” Tableting Course at UT Memphis, June 1998

 

         34.  "SUPAC” Tableting Course at UT Memphis, November 1998

 

Research Grant Awards:

 

Co-Investigator                                                            U.S. Food and Drug                             June 1974-                     $44,850

"Bioavailability                                                             Administration                                       June 1975

Evaluation Program"

   

Co-Investigator                                                            State of Tennessee                              July 1974-                      $130,000

"Drug Quality                                                               Department of                                     June 1975

Assurance Program"                                                    Public Health

   

Co-Investigator                                                            U.S. Food and Drug                             July 1975                        $58,000

"Bioavailability                                                             Administration                                       June 1976

Evaluation Program"

 

Co-Investigator                                                            State of Tennessee                              July 1975                        $130,000

"Drug Quality                                                               Department of                                     June 1976

Assurance Program"                                                    Public Health

   

Co-Investigator                                                            U.S. Food and Drug                             July 1976                        $ 53,300

"Bioavailability                                                             Administration                                       June 1977

Evaluation Program"

   

Co-Investigator                                                            State of Tennessee                              July 1976-                      $     130,000

"Drug Quality                                                               Department of                                     June 1977

Assurance Program"                                                    Public Health

 

Principal Investigator                                                   Cooper Laboratories                            Sept.1976                       $         2,500

"Pharmacokinetics

Use in Developing  Theophylline

Dosage Regimens"

   

Co-Investigator                                                            Bell Pharmacal                                      Feb. 1977                       $           8,000

"Bioavailability Studies"

   

Co-Investigator                                                            Cooper Laboratories                            Mar. 1977                       $        16,000

"Bioavailability Studies"

   

Co-Investigator                                                            Cord Laboratories                                May  1977                      $        16,000

"Bioavailability Studies"

   

Co-Investigator                                                            State of Tennessee                              July 1977-                      $     130,000

"DrugQuality                                                                Department of                                     June 1978

Assurance Program"                                                    Public Health

  

Co-Investigator                                                            Cooper Laboratories                            July 1978                        $        16,200

"Bioavailabiliyv Studies"

 

Co-Investigator                                                            U.S. Food and Drug                             Sept.1977-                      $     271,300

"Bioavailability                                                             Administration                                       Aug. 1980                        

Evaluation Program"

   

Co-Investigator                                                            State of Tennessee                                July 1978-                      $     130,000

"DrugQuality                                                                Department of                                       June 1979

Assurance Program"                                                    Public Health

 

   

Co-Investigator                                                            National Cancer                                    Sept.1978-                      $        27,500

"Clinical Pharma-                                                          Institute - NIH                                      Aug. 1979

cokinetics of Cancer Drugs"

   

Co-Investigator                                                            Cooper Laboratories                            Oct. 1978                        $        17,000

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                              Mar. 1979                       $           7,000

"Sustained-Release                                                                                                                                                                          

Drug Bioavailability"

   

Co-Investigator                                                            Marion Laboratories                            Apr.1979                        $        19,200

"Bioavailability Studies"

   

Co-Investigator                                                            Cooper Laboratories                            June 1979                       $        11,600

"Bioavailability Studies"

   

Co-Investigator                                                            State of Tennessee                              July 1979-                      $     130,000

"Drug Quality                                                               Department of                                       June 1980

Assurance Program"                                                    Public Health

 

Co-Investigator                                                            Pharmadyne Corp.                               Aug. 1979                      $        14,800

"Bioavailability Studies"

 

Co-Investigator                                                            Meyer-Glaxo Labs.                                Dec. 1979                      $        17,000

"Bioavailability Studies"

  

Principal Investigator                                                    Key Pharmaceuticals                           Mar. 1980                       $        25,500

"Bioavailability  Studies"

 

Co-Investigator                                                            Meyer-Glaxo Labs.                               Apr. 1980                       $        24,500

"Bioavailability Studies"

   

Co-Investigator                                                            Berlex Laboratories                              July 1980                        $        13,000

"Bioavailability Studies"

 

Co-Investigator                                                            State of Tennessee                              July 1980-                      $      130,000

"Drug Quality                                                               Department of                                       June 1981

Assurance Program"                                                    Public Health

   

Co-Investigator                                                            U.S. Food and Drug                             Aug. 1980-                     $        35,000

"Bioavailability                                                             Administration                                       Dec. 1980

Evaluation Program"

   

Co-Investigator                                                            Berlex Laboratories                              Oct. 1980                        $        9,800

"Bioavailability Studies"

   

Principal Investigator                                                   Key Pharmaceuticals                           Jan. 1981                        $        29,600

"Bioavailability Studies"

   

Co-Investigator                                                          Glaxo Laboratories                               Jan. 1981                        $        41,000

"Bioavailability Studies"

  

Co-Investigator                                                            ord Laboratories                                Jan. 1981                        $      42,500

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Feb. 1981                       $        22,000

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           May  1981                      $           5,000

"Bioavailability  Studies"

   

Principal Investigator                                                  Bristol-Myers Labs                              July 1981                        $          1,400

"Aspirin Pharmacokine-

tics in Arthritis"

 

Principal Investigator                                                  Key Pharmaceuticals                           July 1981                        $           8,000

"Theophylline Bioavail-

ability Studies"

  

Co-Principal Investigator                                            Key Pharmaceuticals                           Sept.1981                       $        16,000

"Quinidine Bioavail-

ability Studies"

   

Co-Investigator                                                            Cord Laboratories                                 Jan. 1982                       $        26,000

"Metronidazole Bioavailability

Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Feb. 1982                       $        8,800

"Theophylline Bioavailability

Studies"

 

Co-Investigator                                                            Glaxo, Inc.                                              Feb. 1982                       $        34,300

"Ceftazidime Pharmacokinetics

in Renal Patients"

   

Principal Investigator                                                  Key Pharmaceuticals                           July 1982                        $        25,000

"Theophylline Bioavail-

ability Studies"

   

Co-Investigator                                                            State of Tennessee                              July 1982-                      $     180,000

"Drug Quality                                                                                                                               June 1983

Assurance Program"

   

Principal Investigator                                                  Key Pharmaceuticals                           Aug. 1982                      $       11,800

"Bioavailability Studies"

   

Co-Investigator                                                            Glaxo, Inc.                                              Aug. 1982                     $       15,000

"Ceftazidime Pharmacokinetics

During CAPD"

   

Co-Investigator                                                            Pennwalt Corporation                         Sept 1982                       $       28,026

"Bioavailability Studies"

  

Co-Investigator                                                            DuPont Corporation                            Nov. 1982                      $        39,240

"Naltrexone Pharmacokinetics"

   

Principal Investigator                                                  Key Pharmaceuticals                           Nov. 1982                      $         9,000

"Theophylline Bioavail-

ability Studies"

 

 

Co-Principal Investigator                                            Key Pharmaceuticals                           Nov. 1982                      $        14,000

"Bioavailability Studies"

 

Co-Principal Investigator                                            Key Pharmaceuticals                           Dec. 1982                       $        18,000

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Feb. 1983                       $       36,000

"Multiple Dose Drug Studies"

   

Co-Principal Investigator                                            Key Pharmaceuticals                           Feb. 1983                       $        18,000

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Apr. 1983                       $        22,900

"Theophylline Bioavail-

ability Studies"

 

Co-Principal Investigator                                            Key Pharmaceuticals                            July 1983                       $           6,750

"Transdermal Dosing"

   

Co-Investigator                                                            State of Tennessee                              July 1983-                      $     180,000

"DrugQuality                                                                Department of                                       June 1984

 Assurance Program"                                                  Public Health

   

Co-Principal Investigator                                            Glaxo, Inc.                                              Nov. 1983                      $      59,400

"Food Effect on Cefuroxime"

   

Co-Principal Investigator                                            International Drug                               Nov. 1983                      $        65,869

"Aspirin Multiple Dosing"                                         Registration

   

Co-Investigator                                                            Danbury Pharmacal                             Dec. 1983                       $        31,500

"Bioavailability Studies"

   

Co-Principal Investigator                                            Purdue Frederick Co.                           Dec. 1983                       $      28,800

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Jan. 1984                        $        51,000

"Sustained-Release

Theophylline"

   

Co-Principal Investigator                                            Key Pharmaceuticals                           Jan. 1984                        $        11,400

"Bioavailability Studies"

   

Co-Investigator                                                            Pfizer Pharmaceuticals                         Feb. 1984                       $        43,000

"Cefoperazone/Sulbactam"

 

Principal Investigator                                                  Pennwalt Corporation                         Mar. 1984                       $           5,000

"Bioavailability Studies"

 

Co-Investigator                                                            International Drug                               Mar. 1984                       $        31,088

"Bioavailability Studies"                                                Registration

   

Co-Investigator                                                            Purdue Frederick Co.                           Mar. 1984                       $        36,475

"Theophylline Bioavail-

ability Studies"

   

 

Co-Principal Investigator                                            Sidmak Laboratory                               Apr. 1984                       $        24,767

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Apr. 1984                       $        29,330

"Bioavailability Studies"

     

Principal Investigator                                                  Danbury Pharmacal                             May  1984                      $      23,599

"Bioavailability Studies"

   

Co-Investigator                                                            U.S. Food and Drug                             June 1984-                     $     558,000

"Drug Absorption in                                                   Administration                                     June 1987

Achlorhydric Patients"

   

Co-Investigator                                                            State of Tennessee                              July 1984-                      $     180,000

"Drug Quality                                                               Department of                                       June 1985

Assurance Program"                                                   Public Health

   

Principal Investigator                                                  Key Pharmaceuticals                           July  1984                       $        23,526

"Theophylline Bioavail-

ability Studies"

   

Co-Principal Investigator                                            Cord Laboratories                                July 1984                        $        89,000

"Plasma Binding and  Excretion"

   

Co-Investigator                                                            Duramed Pharm.                                   Aug. 1984                      $        16,200

"Absorption Studies"

 

Principal Investigator                                                  Key Pharmaceuticals                           Aug. 1984                      $        21,266

"Theophylline Bioavail-

ability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Sept. 1984                      $        22,000

"Absorption Studies"

   

Co-Investigator                                                            Pennwalt Corporation                         Oct. 1984                        $        36,500

"Bioavailability Studies"

     

Co-Investigator                                                            International Drug                               Nov. 1984                      $       25,000

"Bioavailability Studies"                                              Registration

Principal Investigator                                                  Beecham Laboratories                         Mar. 1985                       $      46,300

"Temocillin Pharmaco-

kinetics"

 

Principal Investigator                                                  Key Pharmaceuticals                           Mar. 1985                       $        11,000

"Bioavailability Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Apr. 1985                       $        17,863

"Steady-State Bioavail-

ability Studies"

 

Co-Investigator                                                            State of Tennessee                              July l985                         $      142,015

"Drug Quality                                                               Department of                                       June l986

Assurance Program"                                                   Public Health

 

 

  

Principal Investigator                                                  Key Pharmaceuticals                            Aug. l985                      $        20,900

"Theophylline Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           Sept.l985                        $        25,600

"Quinidine Studies"

 

Co-Investigator                                                            Quincy Laboratories                            Sept.l985                        $        67,600

Propranolol/Hydrochlorothiazide"

   

Co-Investigator                                                            Cord Laboratories                                Oct. 1985                        $        73,000

"Dipyridamole Bioavailability"

   

Principal Investigator                                                  Glaxo, Inc.                                              Dec. l985                        $        19,700

"Cefuroxime Food Studies"

   

Co-Investigator                                                            Colmed Laboratories                           Jan. l986                         $       32,000

"Dipyridamole Bioavailability"

   

Co-Principal Investigator                                            Cord Laboratories                                Apr. l986                        $        86,540

"Single and Multiple Dose

Theophylline Studies"

   

Co-Investigator                                                            State of Tennessee                              July l986-                       $     142,015

"DrugQuality                                                                Department of                                       June l987

Assurance Program"                                                   Public Health

   

Co-Investigator                                                            Sidmak Laboratories                            May  1986                      $        67,300

"Griseofulvin Absorption"

 

Principal Investigator                                                  Glaxo Laboratories                               May  l986                       $        18,716

"Ranitidine Studies"

   

Principal Investigator                                                  Key Pharmaceuticals                           July l986                         $        21,421

"Gastric pH Effect on

Theophylline Absorption"

   

Principal Investigator                                                  Schering Corporation                          Aug. 1986                      $        16,853

"Single Daily Dosing

 for Theophylline"

 

Co-Investigator                                                            Ganes Chemical Co.,                            Jan. l987                         $        23,500

"Bioavailability Study"                                               New York, NY

   

Co-Investigator                                                            Sidmak Laboratories                            Jan. l987                         $        56,314

"Theophylline Absorption"

   

Principal Investigator                                                  Glaxo, Inc.                                              Jan. l987                         $        22,275

"Theophylline Kinetics"

 

Principal Investigator                                                  Schering Corporation                          Jan. l987                         $        14,786

Pilot Study on Food Effect

on Theophylline Absorption"

 

Co-Investigator                                                            Beecham Laboratories                         Feb. l987                        $        70,000

"Pharmacokinetic Study"

   

Co-Investigator                                                            Dinoseb Task Force II                         Mar. l987                        $         62,500

"Dinoseb Pharmacokinetics"

   

Principal Investigator                                                  Schering Corporation                          Mar. l987                        $        63,120

"Theophylline Studies"

   

Co-Investigator                                                            Vitarine                                                  Mar. l987                        $        32,000

"Dipyridamole Study"

 

Co-Investigator                                                            State of Tennessee                              July l987                         $     142,015

"Drug Quality                                                               Department of                                       June l988

Assurance Program"                                                   Public Health

  

Co-Investigator                                                            Sidmak Laboratories                            May  1987                      $        25,200

"Bioavailability Studies"

   

 Co-Investigator                                                           Sidmak Laboratories                            July l987                         $        97,800

 "Steady-State SR Formulations"

 

Co-Investigator                                                            Siegfried AG                                         Aug. 1987                      $        57,600

"Bioreplication Studies"

   

Principal Investigator                                                  Schering Corporation                          Aug. 1987                      $        30,000

"Theophylline Kinetics at SS"

  

Co-Investigator                                                            US Food and Drug                               Sept.1987-                      $      487,725

"Bioavailability                                                             Administration                                     Sept.1990

  Evaluation" 

     

Co-Investigator                                                            Sidmak Laboratories                            Oct. 1987                        $        64,500

"Bioavailability Studies"

   

Principal Investigator                                                  Schering Corporation                          Nov. 1987                      $        43,800

"SR Theophylline Study"

  

Co-Investigator                                                            IDR                                                         Jan. l988                         $        34,000

"Aspirin Studies"

   

Principal Investigator                                                  Glaxo, Inc.                                              Jan. l988                         $        28,746

"Re-encapsulated Theophylline"

   

Principal Investigator                                                  Schering Corporation                          Feb. l988                        $        63,029

"Food Effect SR Theophylline"

 

Co-Investigator                                                            Sidmak Laboratories                            Mar. 1988                       $        44,200

"Steady-State Study"

   

Co-Investigator                                                            State of Tennessee                              July l988-                       $     142,015

"DrugQuality                                                                Department of                                       June l989

Assurance Program"                                                   Public Health

 

Principal Investigator                                                  Schering Corporation                          Sept.1988                       $        17,820

"Theophylline Kinetics"

  

 

Co-Investigator                                                            Sidmak Laboratories                            Oct. 1988                        $        30,000

"New Assay Methods"

 

Principal Investigator                                                  Schering Corporation                          Nov. 1988                      $        23,640

"Theophylline Bioavailability"

     

Co-Investigator                                                            Sidmak Laboratories                            Nov. 1988                      $        88,000

"Griseofulvin Bioavailability"

 

Principal Investigator                                                  Schering Corporation                          Dec. 1988                       $        27,930

"Theophylline Bioavailability"

     

Co-Investigator                                                            Vitarine Laboratories                           Mar. l989                        $        34,000

"Diazepam Studies"

   

Principal Investigator                                                  ScheringCorporation                           April l989                       $           8,420

"Pediatric Theophylline"

   

Principal Investigator                                                  Kos Pharmaceuticals                           Apr  l989                        $           3,280

"Aspirin Effect on Niacin                                           

Induced Flushing"

  

Co-Investigator                                                            State of Tennessee                              July l989-                       $     106,897

"DrugQuality                                                                Department of                                       June l990

Assurance Program"                                                   Public Health

   

Principal Investigator                                                  Schering Corporation                          Nov. 1989                      $        38,960

"Antacids and Theophylline"

   

Principal Investigator                                                  Schering Corporation                          Dec. 1989                       $        14,850

"Ped S-R Theo Kinetics"

   

Principal Investigator                                                  Schering Corporation                          Dec. 1989                       $        15,120

"Theophylline Kinetics"

   

Principal Investigator                                                  Schering Corporation                          Dec. 1989                       $        16,200

"Steady-State Theophylline"

 

Principal Investigator                                                  Schering Corporation                          Dec. 1989                       $        16,200

"Steady-State Theophylline"

 

"Principal Investigator                                                Kos Pharmaceuticals                           Apr. l990                        $        13,220

"New Dosage Forms"

   

Co-Investigator                                                            State of Tennessee                              July l990-                       $     106,897

"DrugQuality                                                                Department of                                       June l991

Assurance Program"                                                   Public Health

   

Principal Investigator                                                  Schering Corporation                          July 1990                        $        53,840

"Food Effect on Sprinkle"                                              

 

Principal Investigator                                                  Schering Corporation                          Aug. 1990                      $        18,389

"Sprinkle/Intact Dosages

 

Principal Investigator                                                  Kos Pharmaceuticals                           Sep. 1990                       $        31,384

"Food Effect on Absorption"

     

Principal Investigator                                                  Kos Pharmaceuticals                           Dec. 1990                       $        14,400

"Pilot Effect of Food"

   

Principal Investigator                                                  Venture Pharma.                                   Dec. 1990                       $           6,000

"Flux Studies"

   

Principal Investigator                                                  Schering Corporation                          Dec. 1990                       $        58,638

"Single Dose Theophylline"

   

Principal Investigator                                                  Schering Corporation                          Dec. 1990                       $        20,375

"Steady-State Once-a-Day                                        

Theophylline Sprinkle”

 

Co-Investigator                                                            Vitarine                                                  Jan. 1991                        $        31,000

"Bioavailability Studies"

 

Principal Investigator                                                  Schering Corporation                          Jan. 1991                        $        47,082

"Uni-Dur Absorption"

                                                                 

Co-Principal Investigator                                            Hoffman LaRoche                                 Feb. 1991                      $        69,000

"Clonazepam pH Dependent

 Absorption"

   

Co-Prinicpal Investigator                                            Vitarine                                                  Feb. 1991                       $        16,300

"Urinary Excretion of NFT

 

Prinicpal Investigator                                                  Schering Corporation                          Aug. 1991                      $        38,400

"Uni-Dur Analytical"

   

Co-Principal Investigator                                            MD Pharmaceuticals                           July 1991                        $        79,488

"Cyclobenzaprine Absorption"

 

Co-Investigator                                                            State of Tennessee                              July l991-                       $     106,695

"DrugQuality                                                                Department of                                       June l992

Assurance Program"                                                   Public Health

   

Co-Principal Investigator                                            U.S. Food and Drug                             July 1991-                      $     584,575

"Generic Drug Studies"                                               Administration                                     June 1994

   

Principal Investigator                                                  Kos Pharmaceuticals                           Oct. 1991                        $        22,507

 "Transdermal Drug Delivery"

   

Principal Investigator                                                  Sano Corporation                                 Oct. 1991                        $        12,000

"In Vitro Flux Studies"

 

Principal Investigtator                                                 Sano Corporation                                 Nov. 1991                      $        21,900

"Sport Gel in Women"

 

Principal Investigator                                                  Sano Corporation                                 Apr. 1992                       $        12,072

"In Vivo Flux Study"

   

Principal Investigator                                                  Sano Corporation                                 Apr. 1992                       $        21,900

"Sport Gen in Women II"

   

 

Principal Investigator                                                  Whitby Research                                 Aug. 1992                      $      31,759

"SR Theophylline Kinetics"

   

Co-principal Investigator                                            Ciba-Geigy                                            Jan. l993                         $        57,250

"Gastric Emptying and

Enteric Coated Tablets"

  

 

Co-principal Investigator                                            Schering-Plough                                  Mar. 1993                       $        83,000

"Antihistamine Pharmacodynamics"

   

Principal Investigator                                                  Kos Pharmaceuticals                           Apr. l993                        $        36,687

"Absorption of SR Theophylline"

   

 Co-principal Investigator                                           Eon Labs                                               Apr. 1993                       $     170,000

"Multiple Bioavailability Studies"

 

Principal Investigator                                                  Sano Corporation                                 July 1993                        $        28,692

"Transdermal Absorption

of Drugs”

 

Principal Investigator                                                  Timerx Technologies                           Sept 1993                       $        48,234

"SR Drug Release Properties

in Humans”

 

Co-principal Investigator                                            Univ. of Maryland                               July 1993                        $     115,959

"Effect of Formulation                                                 Subcontract FDA

on Piroxicam Absorption”

 

Co-Principal Investigator                                            U.S. Food and Drug                             July 1994-                      $      110,000

"Generic Drug Studies"                                               Administration                                     Jan 1995

                                                                                       

Principal Investigator                                                  Timerx Technologies                           Sept 1994                       $     27,970

"SR Albuterol Food Effects                                       

                                                                                       

Principal Investigator                                                  Timerx Technologies                           Nov 1994                       $     29,193

"Effect of Food on Pseudoephedrine

Absorption in Humans”

 

Principal Investigator                                                  Sano Corporation                                 Jan 1995                         $     29,156

"Transdermal Absorption

of Drugs in Humans”

 

Principal Investigator                                                  Timerx Technologies                           Mar 1995                        $      21,956

"Albuterol Absorption”

 

Principal Investigator                                                  Timerx Technologies                           April 1995                      $      30,736

"Effect of Food on Nifedipine”                                                                                                                                                 

 

Principal Investigator                                                  Timerx Technologies                           April 1995                      $      30,736

"SR Nifedipine Absorpiton

 

Principal Investigator                                                  Timerx Technologies                           May 1995                       $      34,803

"SR Nifedipine Absorpiton

 

Principal Investigator                                                  Sano Corporation                                 Jan 1996                         $     49,478

"Transdermal Absorption

of Drugs in Humans”

 

Principal Investigator                                                  Timerx Technologies                           Aug 1995                       $      44,913

"SR Drug Absorption”

 

Principal Investigator                                                  Timerx Technologies                           Oct 1995                         $      39,714

"Effect of Food on Nifedipine”                                                                                                                                                 

 

Principal Investigator                                                  Timerx Technologies                           Oct 1995                         $      44,913

"SR Nifedipine Absorpiton”

 

Principal Investigator                                                  Timerx Technologies                           Jan 1996                         $      68,906

"SR Nifedipine Absorpiton”

 

 

Principal Investigator                                                  Timerx Technologies                           Jan 1996                         $      39,768

"Effect of Food on Nifedipine”                                                                                                                                                 

 

Co-Investigator                                                            Daniels Pharmaceuticals                     Oct 1995                         $      57,231

"Bioavailability of Dosage Forms”

 

Co-Investigator                                                            Dusa Pharmaceuticals                         Jan 1996                         $      54,340

"IV vs Oral Dosage Forms”

 

Principal Investigator                                                  Timerx Technologies                           July 1996                        $      47,583

"Bioavailability of Dosage Forms”

     

Principal Investigator                                                  Timerx Technologies                           Oct 1996                         $      39,493

"Bioavailability of Dosage Forms”

 

Principal Investigator                                                  Timerx Technologies                           Nov 1996                       $   114,678 

"Bioavailability of Dosage Forms”

 

Co- Investigator                                                           Psoralen, Inc.                                        Dec 1996                        $      16,288

"Bioavailability (Pilot Study)”

 

Co- Investigator                                                           Psoralen, Inc.                                        Dec 1996                        $      59,514

"Bioavailability and Food”

Principal Investigator                                                  Timerx Technologies                           Oct 1997                         $   118,541

"Bioavailability of Dosage Forms”

 

Principal Investigator                                                  Penwest Pharmaceutical                     Jan 1998                         $   174,645

"Bioavailability of Dosage Forms”

 

Principal Investigator                                                  Sano Corporation                                 Jan 1997                         $     26,290

"Drug Flux Studies”

 

Principal Investigator                                                  Penwest Pharmaceutical                     July 1998                        $   22,650

"SR Dosage Forms”

 

 

Co-Investigator                                                            Cogent Pharmaceuticals                     July 1998                        $   62,205

"Transdermal Drug Deliverly”

 

Co-Investigator                                                            Cogent Pharmaceuticals                     Nov 1998                       $    99,570

"Transdermal Deliverly in Elderly”

 

Co-Investigator                                                            Selectus Pharmaceuticals                   Feb 1999                        $    59,850

"Buccal Deliverly System”

 

Co-Investigator                                                            Levotech Pharmaceuticals                  Mar 1999                        $    21,546

"Contraceptive Drug Deliverly”

 

Co-Investigator                                                            Banner Pharmacaps, Inc.                    Mar 1999                        $    89,493    "OTC Analgesic Bioavailability”

 

Prinicpal Investigator                                                  Penwest Pharmaceuticals                   Oct 1999                         $    46,689

"SR Dosage Forms #32

 

Co-Investigator                                                            Alkermes                                               Sept 1999                       $    66,000

"RingCap Dosage Froms”

 

Co-PI                                                                              Focus Pharmaceuticals                       July 1999                        $      13,400

"Isomeric Drug Kinetics”

                                                                                          

Co-PI                                                                              Levotech Pharmaceuticals                  May 2000                       $      59,702

"Contraceptive Delivery System”

 

Principal Investigator                                                  Penwest Pharmaceuticals                   Dec 2000                        $      95,230

"Isomeric Drug Kinetics”

 

Co-PI                                                                              Focus Pharmaceuticals                       Feb 2001                        $      67,888

"Isomeric Drug Kinetics”

 

Co-Principal Investigator                                            U.S. Food and Drug                             Jan 1995-                        $      931,010

"Generic Drug Studies"                                               Administration                                     Jan 2002

 

 

Total Funding                                                                                                                                                       $   12,377,883